Effect of thyroid hormones on noradrenaline-stimulated lipolysis in obesity
Ventz, M.; Meng, W.; Franke, G.; Hampel, R.
Zeitschrift für die Gesamte Innere Medizin und ihre Grenzgebiete 39(12): 282-284
1984
ISSN/ISBN: 0044-2542 PMID: 6485421 Document Number: 241335
11 extremely adipose patients were over 4 days loaded with a noradrenalin infusion of 0.1 microgram/kg body weight/minute over 60 minutes before and after a daily application of 200 micrograms tri-iodothyronine. The determination of the free fatty acids and of glycerin resulted in a significant elevation basally as well as after stimulation with noradrenalin. Thus the lipolytic influence of the thyroid hormones is confirmed under in-vivo-conditions. The possible mechanisms of lipolysis in the fatty tissue are discussed on the basis of literature.