The effect of thyroid hormones on changes in the haptoglobin and transferrin levels in rats
Kuz'mak, N.I.
Problemy Endokrinologii 22(1): 71-75
1976
ISSN/ISBN: 0375-9660 PMID: 1257223 Document Number: 102390
The author presents data concerning the experimental parallel study on male albino rats (171) of the effect of various thyroid hormones on the haptoglobin and transferrin level in the blood serum. On the basis of the data obtained a study was made of the correlation between the changes in the content of iodine-bound protein (IBP) and the mentioned blood glycoproteins in the experimental animals. There was revealed an influence of the thyroid gland on the content and the character of the changes in the haptoglobin and transferrin concentration in the blood serum. Within the range of physiological action thyroid hormones increased the level of blood component data, and in toxic doses--decreased it. The changes in the content of blood glycoproteins depended on the hormone, dosage and the duration of its administration. Between the changes in the concentration of IBP, haptoglobin and transferrin there proved to be a correlation in all the experimental groups with L-thyroxin and triiodthyronin toxicosis. Normalization of the haptoglobin and transferrin level occurred in the majority of the hyperthyroid animals 12 to 24 days after the end of the experiment.