Vitamin C and immunity: influence of ascorbate on prostaglandin E2 synthesis and implications for natural killer cell activity
Siegel, B.V.; Morton, J.I.
International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift für Vitamin- und Ernahrungsforschung. Journal International de Vitaminologie et de Nutrition 54(4): 339-342
1984
ISSN/ISBN: 0300-9831 PMID: 6597182 Document Number: 241241
A regimen of vitamin C in the drinking water of several strains of inbred mice has been observed previously to be without substantial effect on natural killer (NK) cell activity. In the present study, macrophage cultures derived from bone marrow of a number of these strains showed, on the average, a 90-100% increase in prostaglandin E2 (PGE2) production when ascorbate was added. This latter finding might suggest an explanation for the apparent failure of ascorbate to augment NK activity while enhancing interferon production.