Survey of immunoglobulin e levels in atopic families in Israel
Geller-Bernstein, C.; Weisglass, L.; Keret, N.; Dun, R.; Kenett, R.; Bejerano, A.; Lahav, M.; Sela, M.
Israel Journal of Medical Sciences 20(12): 1133-1137
1984
ISSN/ISBN: 0021-2180 PMID: 6519943 Document Number: 240725
Two hundred and ten members belonging to two consecutive generations of 41 atopic families (healthy and affected by clinical atopic manifestations) were investigated for basal immunoglobulin E (IgE) levels and clinical picture. The results show overall increased IgE levels, above standard values in the whole population studied, and a significant correlation between clinical atopy and high IgE levels in the children of the group. Within these families recessive inheritance of abnormally high IgE levels suggests that their high IgE levels are due to a genetically transmitted defect in IgE suppression.