Clinical trial of fosfomycin for Campylobacter enteritis
Nogawa, T.; Takeuchi, Y.; Watanabe, J.; Kimura, K.; Tomii, I.; Abe, T.; Watanabe, Y.; Nakasone, K.; Fujimori, I.; Kobayashi, Y.
Japanese Journal of Antibiotics 37(9): 1620-1624
1984
ISSN/ISBN: 0368-2781 PMID: 6512981 Document Number: 240526
Forty-three children and 4 adults with Campylobacter enteritis were studied in the treatment of fosfomycin (FOM). FOM was administered orally in doses ranging from 50-100 mg/kg per day for children and 3 g/day for adults for 5 days. Main symptoms such as diarrhea and fever disappeared within 2 days on the average. C. jejuni in stool specimen disappeared within 1 wk in 95% of these patients. The duration of main symptoms and the period of positive stool culture were evidently shortened in FOM-treated group compared with non-treated group. All of the isolated strains were sensitive to FOM by mono-concentration disk method. MIC50 of these strains remained between 1.56 and 3.13 .mu.g/ml. None of these MIC was beyond 12.5 .mu.g/ml.