Bone levels of dibekacin
Dellamonica, P.; Etesse, H.; Garraffo, R.; Giaume, F.; Bernard, E.; Argenson, C.
Pathologie-Biologie 32(5): 343-346
1984
ISSN/ISBN: 0369-8114 PMID: 6739143 Document Number: 240341
Levels of an aminoglycoside, dibekacin, are studied in bone. Fifteen specimens were obtained by Tanzer trocar biopsy three hours after the ninth injection of dibekacin (1 mg/kg). Separation of cortical and spongy bone was not feasible owing to the small weight of specimens. Dibekacin concentrations were determined by microbiological assay. These concentrations were evaluated using a reference range in bone tissue determined with the same method and must be corrected according to blood levels. Dibekacin levels were 0.22 +/- 0.10 mg/l in healthy, non- contaminated specimens, and 1.70 and 1.80 mg/l in infected bone tissue.