Significance of selected immunological parameters in the diagnosis and follow-up of systemic lupus erythematosus

Wollina, U.; Knopf, B.; Koch, H.J.

Revista Medico-Chirurgicala a Societatii de Medici Si Naturalisti Din Iasi 88(4): 697-700

1984


ISSN/ISBN: 0048-7848
PMID: 6537639
Document Number: 240288
Immunologic parameters play an important role in the diagnosis assessment, therapy monitoring and follow-up of systemic lupus erythematosus (SLE). Antibodies to dsDNA [double stranded DNA] and Sm are of particular interest in diagnosis, whereas antinuclear antibodies, anti-ssDNA [anti-single stranded DNA] and antibodies against other nuclear constituents are of lower SLE-specificity. The lupus-bandtest is helpful in diagnosis, too. In longitudinal studies anti-dsDNA, circulating immune complexes, and serum complement (C3, C4) are of practical value in the measurement of disease activity and therapeutic efficiency. Cellular diagnosis is likely to become more important. Current methodology is too sophisticated for routine. Some technical characteristics of antibody assays are mentioned briefly.

Document emailed within 1 workday
Secure & encrypted payments