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Regulation of interleukin 2 receptor expression: effects of phorbol diester, phospholipase C, and reexposure to lectin or antigen

Depper, J.M.; Leonard, W.J.; Krönke, M.; Noguchi, P.D.; Cunningham, R.E.; Waldmann, T.A.; Greene, W.C.

Journal of Immunology 133(6): 3054-3061

1984

ISSN/ISBN: 0022-1767
PMID: 6092466
Document Number: 240276
Anti-Tac monoclonal antibody identifies the receptor for interleukin 2 (IL 2, or T cell growth factor) present on activated human T lymphocytes. By using tritiated anti-Tac, a sensitive and specific binding assay to evaluate cell surface IL 2 receptor expression is reported. IL 2 receptors on human peripheral blood lymphocytes can be detected within 6 h after PHA . Similar effects were produced by incubation with phospholipase C but not interleukin 1. Because both PMA and phospholipase C result in activation of protein kinase C, these data suggest the possibility that activation of protein kinase C may induce IL 2 receptor expression.

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