Determination of the antihistaminic properties of histidine derivatives on models of guinea pig T- and B-lymphocyte rosette formation
Sharpan', I.V.
Biulleten' Eksperimental'noi Biologii i Meditsiny 98(10): 503-505
1984
ISSN/ISBN: 0365-9615 PMID: 6333900 Document Number: 239892
It was found that carnosine, like metiamide, an H-2 antagonist of histamine, is capable of inhibiting the histamine caused suppression of T rosette-formation by guinea-pig blood and spleen lymphocytes. The other histidine derivatives, imidazole lactate, imidazole pyruvate and N-acetyl histidine did not exhibit such properties. The data obtained allow classifying carnosine with H-2-histamine blockers and serve as one of the explanations of the mechanism of its antiallergic action.