Once versus twice daily dose of gentamicin therapy in Thai neonates
Kosalaraksa, P.; Janthep, P.; Jirapradittha, J.; Taksaphan, S.; Kiatchoosakun, P.
Journal of the Medical Association of Thailand 87(4): 372-376
2004
ISSN/ISBN: 0125-2208 PMID: 15217172 Document Number: 2398
Objective : To compare the peak and trough gentamicin concentrations in neonates after a once (ODD) vs. twice daily dosing (TDD) to establish the appropriate dosage for Thai neonates. Material and Method : Neonates of gestational age gtoreq 34 weeks, or body weight gtoreq 2000 g, suspected of having bacterial infection were randomized to receive gentamicin intravenously, either 5 mg/kg every 24 hours or 2.5 mg/kg every 12 hours. The peak and trough serum gentamicin levels (SGLs) were measured. Serum creatinine cued nephrotoxicity. Results : Neonates were evaluated and baseline characteristics between the groups were compared. The ODD and TDD group had a mean gentamicin peak and trough concentration of 10.1 +/- 3.0 vs. 7.8 +/- 2.0 mug/ml (p < 0.05) and 1.6 +/- 1.1 vs. 2.6 +/- 1.2 mug/ml (p < 0.05), respectively. The peak SGL of gtoreq 4 mug/ml was achieved in 100% vs. 96% of the ODD vs. TDD group, respectively. SGL troughs gtoreq 2 mug/ml were detected less often in the ODD group (22% vs. 68%; p < 0.05). Abnormal change in serum creatinine was not observed in either group. Conclusion : A once dialy dose of gentamicin 5 mg/kg achieved a significantly higher peak SGL and safer trough than a twice-daily dose of 2.5 mg/kg albeit about a quarter of the ODD group had high troughs. A single daily dose of gentamicin 3.5-4 mg/kg/d in Thai neonates should be tested.
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