Anti-thirst action of propranolol
Zamboni, P.; Persichella, M.; Siro-Brigiani, G.; De Luca, A.
Bollettino della Societa Italiana di Biologia Sperimentale 60(7): 1377-1379
1984
ISSN/ISBN: 0037-8771 PMID: 6477750 Document Number: 239593
A reduction of the thirst was observed one hour after intramuscolar injection of 0.3 mg/kg propranolol in the rat; this effect was not observed with higher doses. According to work hypotheses, small doses could act blocking renal beta-adrenergic receptors: the stopped renin emission reduces angiotensin production that is the basic factor of thirst. The AA hypothesize that the lack of the effect in response to higher doses of propranolol can be explained through a different action of this drug which antagonizes the first one.