Inhibition of endoribonuclease VI from Artemia larvae by cytidine 2'-phosphate
Heredia, C.F.
Biochemical and Biophysical Research Communications 121(1): 408-412
1984
ISSN/ISBN: 0006-291X PMID: 6732817 Document Number: 236361
The endoribonuclease VI from Artemia larvae is noncompetitively inhibited by cytidine 2'-phosphate with a Ki .apprx. 1 .mu.M. Neither of the cytidine monophosphates isomers with the phosphate group in the 3' or 5' position nor the cyclic 2':3' phosphate are inhibitors at concentrations up to 100 .mu.M. Adenosine, guanosine and uridine 2' or 3' phosphates are also ineffective in this range of concentrations. Certain polyribonucleotides are potent competitive inhibitors of the ribonuclease activity.