Effects of chronic desipramine on plasma norepinephrine concentrations and cardiovascular parameters in elderly depressed women: a preliminary report
Cutler, N.R.; Zavadil, A.P.; Linnoila, M.; Scheinin, M.; Rudorfer, M.V.; Potter, W.Z.
Biological Psychiatry 19(4): 549-556
1984
ISSN/ISBN: 0006-3223 PMID: 6733174 Document Number: 236329
The effect of chronic administration of desipramine, a relatively specific inhibitor of the reuptake of norepinephrine (NE), on heart rate, blood pressure, and concentrations of NE in plasma was examined in elderly depressed women. Plasma NE concentrations rose significantly following administration of desipramine, while there was no significant change in either heart rate or blood pressure. Implications of these findings are discussed with relationship to the selection of appropriate types and doses of antidepressants in the elderly.