Mammographic change in hysterectomized women on 0.625 mg/day of conjugated equine estrogen
Panpanit, A.; Muttarak, M.; Pongsatha, S.; Chaovisitsaree, S.; Piyamongkol, W.; Truengthawatchai, S.; Morakot, N.; Sribanditmongkol, N.; Noi-um, S.; Churith, K.; Chuntaranikul, M.
Journal of the Medical Association of Thailand 87(2): 126-130
2004
ISSN/ISBN: 0125-2208 PMID: 15061294 Document Number: 2358
Objective : To compare the mammographic change before and after conjugated equine estrogen (CEE) 0.625 mg/day in hysterectomized women. Design : A retrospective descriptive study. Setting : Menopause clinic, Maharaj Nakorn Chiang Mai Hospital. Material and Method : Dedicated mammograms and demographic data of 66 women who had been hysterectomized were reviewed. Post surgical menopausal women were recruited for the study. CEE 0.625 mg/day was given just after the operation. The baseline mammography was done before the initiation of HRT and they were compared with the follow-up mammography performed 12-18 months after therapy. The degree of increase in mammographic density was classified as follows: minimal changes (10-25% increased density), moderated change (26-50% increased density), and marked change (> 50% increased density). Results : The mean age +/- SD was 47 +/- 4.3 years old. The mean duration SD of hormone used was 13.5 +/- 2.4 months. The most common indication for operation was myoma uteri (43.9%). On the baseline mammogram, 5 cases had cystic change and one case had a small circumscribed solid mass suspected to be fibroadenoma. On the follow-up mammograms, there were 2 cases (3.0%) detected to have significantly increased breast density. One was moderately increased and the other was markedly increased, but cystic changes and one fibroadenoma were not changed. Conclusion : CEE has little effect on increased mammographic density.
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