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Hospital-based diagnosis of hemorrhagic fever, encephalitis, and hepatitis in Cambodian children

Chhour, Y.Meng.; Ruble, G.; Hong, R.; Minn, K.; Kdan, Y.; Sok, T.; Nisalak, A.; Myint, K.Saw.Aye.; Vaughn, D.W.; Endy, T.P.

Emerging Infectious Diseases 8(5): 485-489

2002

ISSN/ISBN: 1080-6040
PMID: 11996683
DOI: 10.3201/eid0805.010236
Document Number: 234906
Surveillance was conducted for three clinical syndromes (hemorrhagic fever, encephalitis, and hepatitis) in Cambodian children admitted to the National Pediatric Hospital in Phnom Penh from July 1996 through September 1998. Acute- and convalescent-phase sera, and cerebrospinal fluid, when applicable, underwent diagnostic evaluation for infections with Dengue virus (DENV), Japanese encephalitis virus (JEV), and Hepatitis A, B, C, and E viruses. Of 621 children admitted with hemorrhagic fever, 499 (80%) were confirmed to have either primary or secondary DENV infection. DENV rates were as high as 10.6/100 hospital admissions in September 1998. Of 50 children with clinical encephalitis, 9 (18%) had serologic evidence of JEV infection. Forty-four children had clinical hepatitis, most (55%) due to Hepatitis A virus (HAV). One patient had Hepatitis B virus, and no patients had hepatitis C or E. This study identified a large number of children with vaccine-preventable diseases (JEV and HAV).

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