Behavioral toxicological assessment of oral pralidoxime methanesulfonate in the rat
Liu, W.F.; Hu, N.W.; Beaton, J.M.
Neurobehavioral Toxicology and Teratology 6(2): 121-127
1984
ISSN/ISBN: 0275-1380 PMID: 6472556 Document Number: 234783
The behavioral toxicity of pralidoxime methanesulfonate (P2S) toxicity. P2S produced a weak CTA at doses of 0.4 and 0.8 g/kg (PO) and a profound CTA at the highest dose (1.6 g/kg) using a single sucrose-flavored conditioning trial with a 1 bottle test. The CTA produced by the highest dose of P2S was blocked by a specific, and exclusively peripheral, histamine-H2-blocker, cimetidine (30 mg/kg, i.p.), which also has a cytoprotecting effect on gastric mucosal lesions. H2 receptors may be involved in inducing the aversive effects of P2S through the inherent local irritating property of P2S on the rat gastric mucosa. There was no disruption of water drinking in thirsty rats with P2S at doses 0.2-1.6 g/kg. The survival time after an acute oral lethal dose of P2S (8-15 g/kg) was prolonged in non-fasted rats (16.5-38.5 min) compared to fasted ones (3.5-14.5 min), but LD50 were identical (8.7 .+-. 1.0 and 7.5 .+-. g/kg; respectively); indicating that P2S taken with food delays the lethal effects, but does not affect its lethal potency.