Central therapeutic effects of dihydroderivative of pralidoxime (pro-2-PAM) in organophosphate intoxication
Rump, S.; Faff, J.; Borkowska, G.; Ilczuk, I.; Rabsztyn, T.
Archives Internationales de Pharmacodynamie et de Therapie 232(2): 321-332
1978
ISSN/ISBN: 0003-9780 PMID: 677965 Document Number: 124234
Central actions of pro-2-PAM (dihydroderivative of 2-PAM) and 2-PAM in poisonings with DFP have been studied. It was shown that pro-2-PAM significantly increased activity of DFP inhibited acetylcholinesterase in the brain, quickly ceased the DFP-induced paralysis of respiration, partially normalized the DFP-induced abnormalities in electrocorticogram and increased the convulsive dosis of DFP. Effects of 2-PAM in these experiments were negligible.