N-quaternary derivatives of tilorone
Schulze, W.; Letsch, G.; Gutsche, W.; Wohlrabe, K.; Tresselt, D.
Die Pharmazie 39(5): 320-322
1984
ISSN/ISBN: 0031-7144 PMID: 6473490 Document Number: 234386
Tilorone (free base) reacts with alkyl halides forming quaternary ammonium salts. Bis- as well as mono quaternary compounds (2 resp. 3) were synthesized. The tilorone-bis-methoiodide (2a) was converted to several carbonyl derivatives (4 and 5). All produced compounds did not show any cytostatic activity against the murine leukemias L 1210 and P 388 in vivo. Especially the bis-quaternary derivatives 2 were highly toxic in the mouse.