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Effect of calcium blockers on the morphofunctional state of the capillary system of the cerebral cortex

Gabrielian, E.S.; Matevosian, R.S.

Biulleten' Eksperimental'noi Biologii i Meditsiny 98(9): 310-312

1984

ISSN/ISBN: 0365-9615
PMID: 6091809
Document Number: 233676
The use of the non-injection method for determination of the intraorgan microcirculatory bed in cats has shown that calcium channels play an important role in the functioning of precapillary sphincters, whose activity depends to a greater extent on the activity of alpha-adrenoreceptors, particularly alpha 1-receptors. The so-called "gaiting mechanism" of calcium channels plays a more essential part in the changes in the basal tone of precapillary sphincters influenced by calcium antagonists, whereas voltage-controlled and receptor-operated calcium channels are responsible for variations in the adrenergic tone of precapillary sphincters.

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