Cardiovascular and respiratory effects of spermidine and spermine: an experimental study
Marmo, E.; Berrino, L.; Cazzola, M.; Filippelli, A.; Cafaggi, G.; Persico, N.; Spadaro, R.; Nisticò, G.
Biomedica Biochimica Acta 43(4): 509-515
1984
ISSN/ISBN: 0232-766X PMID: 6207813 Document Number: 232961
Spermidine (SPD) and spermine (SPM) produced significant cardiovascular changes in anesthetized dogs at higher doses than other transmitters, i.e., 1-noradrenaline , histamine, acetylcholine, which produce cardiovascular effects at doses of 0.01-0.05 .mu.g/kg given i.v. SPD was shown to be more active than SPM. The hypotensive response-observed after i.v. injection is due to histamine release. The hypotensive and bradycardic effects observed after microinjection of SPD into III cerebral ventricle or into the vertebral artery, and of SPM into the vertebral artery, are due to an increase in parasympathetic output. Spermidine increased and spermine decreased the baroreceptor reactivity. SPD and SPM did not change the vascular .beta.- and .alpha.-adrenergic, cholinergic and histaminergic receptor reactivity.