Malaria caused by multi-resistant Plasmodium falciparum contracted in Tanzania
Mazier, D.; Danis, M.; Druilhe, P.; Karabinis, A.; Brucker, G.; Félix, H.; Gentilini, M.
Bulletin de la Societe de Pathologie Exotique et de Ses Filiales 77(1): 44-51
1984
ISSN/ISBN: 0037-9085 PMID: 6373034 Document Number: 232862
In a severe case of malaria, the chemosensitivity of a Plasmodium falciparum strain from a traveller to Tanzania who underwent chemoprophylaxis treatment with chloroquine (600 mg weekly) was evaluated in vitro. In the 28 hours maturation assay and a 72 hours proliferation assay, the strain proved to be highly resistant to chloroquine and to have a reduced sensibility to the sulfadoxin - pyrimethamin association.