Oxidative degradation of thymine with O2 promoted by L-ascorbic acid and Cu (II) ion
Ito, S.; Kinoshita, T.; Sasaki, K.
Nucleic Acids Symposium Series 15: 5-8
1984
ISSN/ISBN: 0261-3166 PMID: 6522293 Document Number: 232282
Oxidation of thymine with O2 was promoted by copper(I) ion generated from reaction of L-ascorbic acid (AA) with copper (II) ion. The main oxidation products were thymine glycol (TG) and N-formyl-N'-pyruvylurea (FPU). At higher concentration of O2, formation of FPU was favored, while TG was dominant at higher Cu(II) ion and lower O2 concentrations. Reaction mechanism involving hydroxy thyminyl radical was proposed.
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