Direct evidence for the expression of integrated hepatitis B virus DNA in human hepatoma tissue
Yaginuma, K.; Kobayashi, H.; Yoshida, E.; Kobayashi, M.; Koike, K.
Gan 75(9): 743-746
1984
ISSN/ISBN: 0016-450X PMID: 6094294 Document Number: 231697
The intracellular structure and expression of integrated hepatitis B virus (HBV) DNA in the hepatoma tissue #1707 obtained from an 11-year-old boy were studied. It was found that most of the HBV genome was present in the #1707 DNA. Virus-specific 21S mRNA was also demonstrated by blot hybridization. This is the first direct evidence for the expression of the integrated viral genome in human hepatoma tissue.
Document emailed within 1 workday
Related Documents
Bian, Z.-q.; Liu, S.; Liu, M.-q.; Xiao, A.; Jiao, Y.; Yan, W.-y.; Zheng, Z.-x. 2012: PreC/C gene-targeting RNA interference suppresses hepatitis B virus replication and expression in human hepatoma cells Zhonghua Yi Xue Za Zhi 92(11): 768-772Terris, B.; Marchio, A.; Mattei, M.G.; Fagan, E.; Lok, A.; Tiollais, P.; Dejean, A. 1992: Abnormal expression of hepatitis B virus sequences integrated in human hepatocellular carcinomas Gastroenterologie Clinique et Biologique 16(6-7): 511-517
Wang, W.; Gu, G.; Hu, M. 1996: Expression and significance of hepatitis B virus genes in human primary intrahepatic cholangiocarcinoma and its surrounding tissue Zhonghua Zhong Liu Za Zhi 18(2): 127-130
Shang, Q.; Zhang, G.; Xu, C.; Chen, C.X.; Yu, J.G.; Yan, C.Y. 2001: Expression of hepatitis B virus antigen in brain tissue from liver cirrhosis patients with hepatitis B and its significance Zhonghua Shi Yan he Lin Chuang Bing du Xue Za Zhi 15(3): 277-279
Chen, H.; Yeh, S.F.; Ong, G.T.; Wu, S.H.; Sun, C.M.; Chou, C.K. 1995: The novel desmethyldestruxin B2, from Metarhizium anisopliae, that suppresses hepatitis B virus surface antigen production in human hepatoma cells Journal of Natural Products 58(4): 527-531
Bagnarelli, P.; Brugia, M.; Clementi, M. 1985: A serum-free growth of a human hepatoma cell line as a tool for hepatocarcinogenesis and virus gene expression Developments in Biological Standardization 60: 45-53
Tang, S.B.; Schemiffarth, O.F.; Lund, O.E. 1993: Direct identification of herpes simplex virus type-1 in human corneal tissue. Methodology and application of in situ DNA hybridization technique Chinese Medical Journal 106(2): 122-126
Kozlovskaia, T.M.; Pumpen, P.P. 1986: Structure and expression of human hepatitis B virus surface antigen Molekuliarnaia Biologiia 20(4): 884-901
Sungkanuparph, S.; Vibhagool, A.; Manosuthi, W.; Kiertiburanakul, S.; Atamasirikul, K.; Aumkhyan, A.; Thakkinstian, A. 2004: Prevalence of hepatitis B virus and hepatitis C virus co-infection with human immunodeficiency virus in Thai patients: a tertiary-care-based study Journal of the Medical Association of Thailand 87(11): 1349-1354
Adoga, M.P.; Banwat, E.B.; Forbi, J.C.; Nimzing, L.; Pam, C.R.; Gyar, S.D.; Agabi, Y.A.; Agwale, S.M. 2009: Human immunonodeficiency virus, hepatitis B virus and hepatitis C virus: sero-prevalence, co-infection and risk factors among prison inmates in Nasarawa State, Nigeria Journal of Infection in Developing Countries 3(7): 539-547
Chung, D.C.; Ko, Y.C.; Chen, C.J.; Chen, E.R.; Wu, C.C.; Wu, P.S. 1989: Seroepidemiology of hepatitis B virus, hepatitis D virus, and human immunodeficiency virus infections among parenteral drug abusers in southern Taiwan Journal of Medical Virology 28(4): 215-218
Kazi, A.M.; Shah, S.A.; Jenkins, C.A.; Shepherd, B.E.; Vermund, S.H. 2010: Risk factors and prevalence of tuberculosis, human immunodeficiency virus, syphilis, hepatitis B virus, and hepatitis C virus among prisoners in Pakistan International Journal of Infectious Diseases: Ijid: Official Publication of the International Society for Infectious Diseases 14(Suppl 3): E60-E66
Calderón, G.M.; González-Velázquez, F.; González-Bonilla, C.R.; Novelo-Garza, B.ár.; Terrazas, J.J.; Martínez-Rodríguez, M.L.; Cortés-Márquez, S.R.; Blanco-Flores, J.P.; Rodríguez-Rodríguez, A.; Del Campo, M.A.; Cortés-Gómez, R.; Mejía-Bocanegra, M.G. 2009: Prevalence and risk factors of hepatitis C virus, hepatitis B virus, and human immunodeficiency virus in multiply transfused recipients in Mexico Transfusion 49(10): 2200-2207
Cao, J.-y.; Liang, M.-f.; Meng, Q.-l.; Wang, X.-f.; Xu, Y.-g.; Guo, K.-q.; Zhan, M.-y.; Bi, S.-l.; Li, D.-x. 2004: Baculovirus expression of two human recombinant neutralizing IgG monoclonal antibodies to hepatitis a virus Zhonghua Shi Yan he Lin Chuang Bing du Xue Za Zhi 18(1): 20-23
Ruzibakiev, R.; Kato, H.; Ueda, R.; Yuldasheva, N.; Hegay, T.; Avazova, D.; Kurbanov, F.; Zalalieva, M.; Tuichiev, L.; Achundjanov, B.; Mizokami, M. 2001: Risk factors and seroprevalence of hepatitis B virus, hepatitis C virus, and human immunodeficiency virus infection in uzbekistan Intervirology 44(6): 327-332
Kania, D.; Sangaré, L.; Sakandé, J.; Koanda, A.; Nébié, Y.K.; Zerbo, O.; Combasséré, A.W.; Guissou, I.P.; Rouet, F.ço. 2009: A new strategy to improve the cost-effectiveness of human immunodeficiency virus, hepatitis B virus, hepatitis C virus, and syphilis testing of blood donations in sub-Saharan Africa: a pilot study in Burkina Faso Transfusion 49(10): 2237-2240
Lewis, A.P.; Lemon, S.M.; Barber, K.A.; Murphy, P.; Parry, N.R.; Peakman, T.C.; Sims, M.J.; Worden, J.; Crowe, J.S. 1993: Rescue, expression, and analysis of a neutralizing human anti-hepatitis A virus monoclonal antibody Journal of Immunology 151(5): 2829-2838
Devi, K.S.; Singh, N.B.; Singh, H.L.; Singh, Y.M. 2009: Coinfection by human immunodeficiency virus, hepatitis B virus and hepatitis C virus in injecting drug users Journal of the Indian Medical Association 107(3): 144; 146-147
Kasprzak, A.; Zabel, M.; Wysocki, J.; Seidel, J.; Surdyk-Zasada, J.; Filipiak, B. 2002: Expression of mRNA for cytokines (TNF-alpha and IL-1alpha) in human cytomegalovirus (HCMV) and hepatitis B virus (HBV) infections Folia Histochemica et Cytobiologica 40(2): 63-68
Eligini, S.; Banfi, C.; Brambilla, M.; Camera, M.; Barbieri, S.S.; Poma, F.; Tremoli, E.; Colli, S. 2002: 15-deoxy-delta12,14-Prostaglandin J2 inhibits tissue factor expression in human macrophages and endothelial cells: evidence for ERK1/2 signaling pathway blockade Thrombosis and Haemostasis 88(3): 524-532