Protective action of double-stranded complexes--interferon inducers in encephalomyocarditis in mice
Nosik, N.N.; Lavrukhina, L.A.; Ershov, F.I.
Biulleten' Eksperimental'noi Biologii i Meditsiny 97(4): 446-448
1984
ISSN/ISBN: 0365-9615 PMID: 6326886 Document Number: 230551
Interferon inducers, dsRNA and poly (G) X poly (C) ( polyguacyl ), injected into mice intraperitoneally induced interferon formation, the maximal activity being equal to 640-1280 U/ml. Antiviral effect of the inducers was studied upon intraperitoneal and intracerebral injections. Both polyguacyl and dsRNA exerted a marked antiviral action against infection induced by murine encephalomyocarditis virus. The most powerful effect was attained when the inducers were injected 24 or 4 h before challenge. The protective action was produced by polyguacyl and dsRNA even after intracerebral infection. There is a good agreement between the interferon-inducing and antiviral activity of interferon inducers. The data obtained demonstrate the fitness of experimental encephalomyocarditis of mice for testing interferon inducers.