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Lactoferrin interacts with deoxyribonucleic acid: a preferential reactivity with double-stranded DNA and dissociation of DNA-anti-DNA complexes

Bennett, R.M.; Davis, J.

Journal of Laboratory and Clinical Medicine 99(1): 127-138

1982

ISSN/ISBN: 0022-2143
PMID: 6274982
Document Number: 184755
Lactoferrin (LF) was isolated from pooled human milk. Immunofluorescence studies of mouse liver cell nuclei incubated with LF, electroimmunodiffusion of LF with or without DNA, gel chromatography of an LF-DNA reaction mixture, affinity chromatography of single- and double-stranded DNA on a column of immobilized LF, and enzymic digestion of LF-DNA complexes, suggested preferential reactivity of LF with double-stranded DNA. Studies using sera from patients with systemic lupus erythematosus (SLE) revealed that LF inhibited DNA-anti DNA binding and dissociated DNA-anti DNA complexes. A role for LF released by neutrophils in the inflammatory response in SLE is proposed.

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Al-Mendalawi, M.D. 2011: Medical conditions associated with a positive anti-double-stranded deoxyribonucleic acid Saudi Medical Journal 32(2): 204; Author Reply 204
Li, L.H.; Swenson, D.H.; Schpok, S.L.; Kuentzel, S.L.; Dayton, B.D.; Krueger, W.C. 1982: CC-1065 (NSC 298223), a novel antitumor agent that interacts strongly with double-stranded DNA Cancer Research 42(3): 999-1004
Krey, A.K.; Olenick, J.G.; Hahn, F.E. 1976: Interactions of the antibiotic distamycin a with homopolymeric single-stranded polydeoxyribonucleotides and with phiX 174 deoxyribonucleic acid Molecular Pharmacology 12(1): 185-190
Waschke, K.; Waschke, S.R.; Hoffman, S.; Witkowski, W. 1977: Interferon induction by double-stranded like complexes of vinyl copolymers with polynucleotides Archivum Immunologiae et Therapiae Experimentalis 25(5): 627-630
Nosik, N.N.; Lavrukhina, L.A.; Ershov, F.I. 1984: Protective action of double-stranded complexes--interferon inducers in encephalomyocarditis in mice Biulleten' Eksperimental'noi Biologii i Meditsiny 97(4): 446-448
Almogren, A. 2010: Anti-double stranded antibody. Association with titers and fluorescence patterns of anti-nuclear antibody in systemic lupus erythematosus Saudi Medical Journal 31(1): 32-36
Huber, O.; Greenberg, M.L.; Huber, J. 1979: Complement-fixing anti--double-stranded DNA with the Crithidia method: a better indicator of active SLE than anti-DNA with the Farr method Journal of Laboratory and Clinical Medicine 93(1): 32-39
Min, D.J.; Kim, S.J.; Park, S.H.; Seo, Y.I.; Kang, H.J.; Kim, W.U.; Cho, C.S.; Kim, H.Y. 2002: Anti-nucleosome antibody: significance in lupus patients lacking anti-double-stranded DNA antibody Clinical and Experimental Rheumatology 20(1): 13-18
Monier, J.C.; Perraud, M.; Chevallier, P.H.; Sepetjan, M.; Trepo, C. 1979: Absence of anti double stranded DNA antibodies in viral hepatitis La Nouvelle Presse Medicale 8(29): 2395-2398
Strel'tsov, S.A.; Semenov, T.E.; Moroz, O.V. 1993: The hierarchy of complexes and compact structures of trivaline with nucleic acids. I. Interaction of trivaline with double-stranded DNA Molekuliarnaia Biologiia 27(5): 1165-1182
Fish, F.; Ziff, M. 1982: The in vitro and in vivo induction of anti-double-stranded DNA antibodies in normal and autoimmune mice Journal of Immunology 128(1): 409-414
Peltier, A.P.; Hughes, G.R.; Kahn, M.F.; Haim, T. 1974: Detection of serum anti-deoxyribonucleic acid antibodies by Farr's radioimmunoassay La Nouvelle Presse Medicale 3(11): 649-653
Winfield, J.B.; Shaw, M.; Taylor, R.P.; Eisenberg, R.A. 1981: Nature of double-stranded DNA binding activity in seropositive rheumatoid arthritis: formation of low avidity DNA/rheumatoid factor/IgG/low density lipoprotein complexes Journal of Immunology 126(4): 1596-1602
Epstein, W.V. 1975: Specificity of SLE serum antibody for single-stranded and double-stranded DNA configuration Journal of Rheumatology 2(2): 215-220
Kubota, T.; Kanai, Y. 1989: Expression of anti-double stranded DNA idiotype in mixed connective tissue disease and progressive systemic sclerosis Bulletin of Tokyo Medical and Dental University 36(2): 13-18
Carsana, A.; Lavitrano, M.L.; Libonati, M. 1984: Proteins with preferential affinity for single-stranded DNA in tissues of Octopus vulgaris lam Italian Journal of Biochemistry 33(2): 88-97
Timofeev, V.P.; Arutiunian, A.I.; Petrov, A.I. 1990: Segmental flexibility of single-, double-, and triple-stranded polyribonucleotides from the data of spin label method. Formation of the triple-stranded poly(A.A.U) polynucleotide helix Molekuliarnaia Biologiia 24(1): 140-155
Nishiya, K.; Chikazawa, H.; Matsumori, A.; Chijiwa, T.; Tahara, K.; Morita, T.; Hosokawa, T.; Ito, H.; Hashimoto, K.; Fujieda, M. 1999: Anti-myeloperoxidase and anti-lactoferrin antibodies in patients with IgA nephropathy and Henoch-Schönlein purpura Rinsho Byori. Japanese Journal of Clinical Pathology 47(2): 185-187
Bondarev, A.I.; Bashkatov, S.A.; Davydova, V.A.; Zarudiĭ, F.S.; Lazareva, D.N.; Tolstikova, T.G.; Baltina, L.A.; Tolstikov, G.A.; Murinov, I.I.; Rusakov, I.A. 1991: The anti-inflammatory and analgesic activities of antiphlogistic complexes with glycyrrhizic acid Farmakologiia i Toksikologiia 54(5): 47-50
Souroujon, M.; White-Scharf, M.E.; Andreschwartz, J.; Gefter, M.L.; Schwartz, R.S. 1988: Preferential autoantibody reactivity of the preimmune B cell repertoire in normal mice Journal of Immunology 140(12): 4173-4179