Primary structure of alpha-lytic protease: a bacterial homologue of the pancreatic serine proteases
Olson, M.O.; Nagabhushan, N.; Dzwiniel, M.; Smillie, L.B.; Whitaker, D.R.
Nature 228(5270): 438-442
1970
ISSN/ISBN: 0028-0836 PMID: 5482494 Document Number: 23050
Comparison of the amino-acid sequence of the bacterial α-lytic protease with the mammalian pancreatic proteases shows homologies in the regions of the N-terminus, the single histidine, an aspartic acid residue, the active serine, and in the positions of the three disulphide bridges. The partial sequence of a trypsin-like enzyme from Streptomyces griseus provides further evidence for divergent evolution of this class of enzymes from a common ancestral gene.