Varicella and herpes zoster in immunosuppressed children: preliminary results of treatment with intravenous immunoglobulin
Sulliger, J.M.; Imbach, P.; Barandun, S.; Gugler, E.; Hirt, A.; Lüthy, A.; Rossi, E.; Tönz, O.; Wagner, H.P.
Helvetica Paediatrica Acta 39(1): 63-70
1984
ISSN/ISBN: 0018-022X PMID: 6609911 Document Number: 230174
Seven immunosuppressed children with varicella and two with herpes zoster were treated with large intravenous doses of polyvalent, intact immunoglobulin (IgG i.v.). In all patients the treatment was effective for controlling fever and skin lesions and for preventing progression and complications, even if this therapy was started late and/or if the patient was severely lymphopenic . More IgG was needed to control disseminated than less advanced varicella. No untoward effects of IgG therapy were observed. The preliminary results suggest that in future trials i.v. IgG should be used for comparison with antiviral agents.