Sinoaortic baroreceptors and the control of blood volume in the nonhuman primate
Cornish, K.G.; McCulloch, T.; Gilmore, J.P.
American Journal of Physiology 247(4 Pt 2): F539-F542
1984
ISSN/ISBN: 0002-9513 PMID: 6496681 Document Number: 229923
The purpose of this study was to determine the role of the aortic and carotid baroreceptors in regulating blood volume in the conscious non-human primate. Eighteen control animals were surgically instrumented to permit the recording of blood pressure, pulse rate, and left atrial pressure. After a urethral catheter was inserted into the bladder, the animals were given an intravenous infusion equal to 20% of the estimated blood volume. Renal function was determined before and after the volume expansion. Nine monkeys received the same infusion after undergoing chronic sinoaortic denervation. The denervated animals responded with a potentiated diuresis and natriuresis. The control animals excreted 24% of the infused volume and 4% of the infused salt while the sinoaortic-denervated animals excreted a volume equal to 113% of that infused and an amount of sodium equal to 46% of that infused. We conclude that high-pressure receptors exert an inhibitory influence on whatever mechanisms are involved in the renal response to acute volume expansion.