Estimation of the intensity of effect of cardenolides. 2: Algorithms for the estimation of the intensity of effect
Köpke, K.; Dittrich, F.; Berlin, P.
Die Pharmazie 39(4): 256-258
1984
ISSN/ISBN: 0031-7144 PMID: 6739530 Document Number: 229535
An algorithm worked on basis of quantitative relations between molecular-biologically defined effects and molecular-physical properties (see part 1) allows the effect estimation of concepted cardenolides before their synthesis. The empirical use of the developed equations for the estimation of molecular-biologically defined effect of compounds produces usable results and justifies therefore the proposed method, as well as it's shown by the experimental proof of estimated values of some cardenolides . An enlargement of the use of the algorithm for effect estimation seems to be successful.