Effect of luliberin and chorionic gonadotropin on luteinizing hormone and testosterone levels in the blood of monkeys under acute stress
Katsiia, G.V.; Chirkov, A.M.; Goncharov, N.P.
Problemy Endokrinologii 30(1): 73-77
1984
ISSN/ISBN: 0375-9660 PMID: 6369303 Document Number: 229518
The effect of immobilization stress on luteinizing hormone (LH) and testosterone (T) secretion following injections of luliberin (LH-RH) and human chorionic gonadotropin (HCG) was investigated in male hamadryas baboons. It was established that in control animals a single injection of HCG (4500 IU) led to a more prolonged and more demonstrable increase of plasma testosterone concentration than injection of a pharmacological dose (100 micrograms) of LH-RH. Preliminary stimulation of the testes with LH-RH did not prevent the stress-induced inhibition of testosterone despite the fact that LH secretion in intact and stress-exposed baboons did not differ significantly over 2.5 h after drug injection. At the same time stress did not inhibit the testicular response in baboons pretreated with HCG (4500 IU), although the level of T concentration in stress-exposed animals was lower than in control. The data obtained suggest that disturbed interaction between hypophyseal tropic hormone and the testes underlie the inhibitory effect of stress.