Immature Paneth cells in intestinal metaplasia of gastric mucosa
Albedi, F.M.; Lorenzetti, E.; Contini, M.; Nardi, F.
Applied Pathology 2(1): 43-48
1984
ISSN/ISBN: 0252-1172 PMID: 6525318 Document Number: 228851
Various histochemical techniques were performed on paraffin sections of gastric mucosa from patients with intestinal metaplasia to distinguish mature from immature Paneth cells (PC) and to correlate their relative incidence with the degree of differentiation of metaplastic epithelium. The results show a higher incidence of immature PC in the poorly differentiated type of intestinal metaplasia than in the well-differentiated type. The identification of immature PC may be proposed as a further criterion in the evaluation of gastric dysplasia.