Immunoenzymatic detection of circulating antitumor antibodies in the rat: development of a quantitative technic and its use in rats bearing grafted colonic tumors
Thomas, B.; Olsson, O.; Martin, F.
Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales 178(5): 506-511
1984
ISSN/ISBN: 0037-9026 PMID: 6241023 Document Number: 228810
In order to study the humoral immune response of rats against a colonic tumor, we developed an immuno-enzymatic technique for quantitating specific anti-tumoral antibodies. This technique which uses a monolayer of intact cancer cells as antigen produces objective and reproducible results. Applied to eleven rats carrying grafted colon carcinomas, it allowed the characterization of three different types of evolution of the concentration of circulating antibodies.