Further evidence of the antiarrhythmic efficacy of taurine in the rat heart
Hernández, J.; Artillo, S.; Serrano, M.I.; Serrano, J.S.
Research Communications in Chemical Pathology and Pharmacology 43(2): 343-346
1984
ISSN/ISBN: 0034-5164 PMID: 6709969 Document Number: 228339
The potential antidysrrhythmic effect of taurine has been studied both "in vitro" and "in vivo". "In vitro experiments were performed on a model of automaticity induced in the isolated right ventricle of the rat. The "in vivo" studies have been done on anesthetized rats, assessing the effect of taurine on the electrical activity of the heart by continuous ECG records. Taurine decreases the "in vitro" automatic ventricular frequency. "In vivo" reduces heart rate (P-P interval increases) and conduction through the ventricular myocardium (prolongs QRS interval duration). We conclude that taurine possesses experimentally antidysrrhythmic activity "in vitro" and "in vivo", that would warrant further research.