Cerebral antioedematous effect of Teproside and of some vincamine derivatives
Borzeix, M.G.; Cahn, J.
International Journal of Clinical Pharmacology Research 4(4): 259-261
1984
ISSN/ISBN: 0251-1649 PMID: 6500773 Document Number: 228093
Alkyltin compounds produce in the rat selective CNS edema, especially of the white matter. Vincamine and vincamine derivatives, among which Teproside is the most potent, can prevent the occurrence of such an edematous reaction while xanthine derivatives and papaverine fail to prevent this edema. There may be a potentiation of the effect of vincamine by the xanthine part of the Teproside chemical structure.