An aorto-esophageal fistula in a patient with malignant lymphogranuloma
Peychlová, J.; Cermák, J.
Ceskoslovenska Patologie 20(3): 177-182
1984
ISSN/ISBN: 1210-7875 PMID: 6499019 Document Number: 227994
A 25-year-old man suffering from lymphogranuloma malignum received mediastinal radiotherapy in a dose of 3,380 R (827 mC/1 kg). About 2,5 years later fatal gastro-intestinal haemorrhage occurred from a aortooesophageal fistula. Aortic necrosis of media and intima with G+ cocci was found, as well as adventitial fibrosis with radiation fibroblasts. Assisting mechanisms of aortic damage by therapeutic doses of radiation were discussed.