Serous papillary cystadenocarcinoma associated with alpha-fetoprotein production
Higuchi, Y.; Kouno, T.; Teshima, H.; Akizuki, S.; Kikuta, M.; Ohyumi, M.; Yamamoto, S.
Archives of Pathology and Laboratory Medicine 108(9): 710-712
1984
ISSN/ISBN: 0003-9985 PMID: 6205636 Document Number: 227578
A 74-year-old woman with a right ovarian tumor had a high level of the serum tumor marker alpha-fetoprotein (AFP). After combination chemotherapy, the serum AFP level decreased significantly. Histopathologic study of surgically excised tumor tissue revealed a serous papillary cystadenocarcinoma. By the indirect immunoperoxidase technique, the AFP was stained in the cytoplasm of the differentiated tumor cells, showing papillary or tubular structures. Serial sections showed that the cells containing PAS-positive substances did not correspond to those producing AFP.