Doxycycline in experimental rickettsial infection
Kekcheeva, N.G.
Antibiotiki 29(10): 775-780
1984
ISSN/ISBN: 0003-5637 PMID: 6439108 Document Number: 227108
The effect of doxycycline on Rickettsia prowazekii and R. sibirica was studied in comparison with that of tetracycline on 2 infection models, i.e., chick embryos and guinea pigs. The activity of doxycycline in the experiments with chick embryos was higher than that of tetracycline, the drug being more active against R. prowazekii than R. sibirica. The use of doxycycline in the treatment of the guinea pigs infected with R. prowazekii resulted in very rapid and stable decrease of the temperature. When used within the incubation period the drug prevented the infection development. Doxycycline was less effective in infections caused by R. sibirica.