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Efficacy and value of fibrinolytic agents in chronic proximal venous thrombosis of the lower limbs

Bonnet, J.; Colle, J.P.; Lorient-Roudaut, M.F.; Vergnes, C.; Haissaguerre, M.; Boisseau, M.R.; Bricaud, H.

Archives des Maladies du Coeur et des Vaisseaux 77(9): 1033-1039

1984

ISSN/ISBN: 0003-9683
PMID: 6435579
Document Number: 227104
Forty patients (mean age = 56 +/- 17 years) hospitalized for proximal venous thrombosis of the lower limbs of over 7 days duration were treated with fibrinolytic drugs: streptokinase (SK) 28 cases, urokinase (UK) 12 cases. The efficacy of fibrinolytic therapy was assessed by phlebography before and 4.5 +/- 2 days after onset of treatment. A phlebographic score based on Marder's method was used to quantify the thrombosis. The repermeabilisation of venous branches was also noted. The results show an overall efficacy of fibrinolytic drugs: total lysis was observed in 6 patients and partial thrombolysis in 18 patients. The overall reduction of the phlebographic score was -2.8 +/- 3.9, and the rate of repermeabilisation of the femoral veins was over 50%. Streptokinase seemed to be the most effective drug. Better results were obtained when the thrombosis was treated early and was proximally situated, but good results were also observed in cases of total thrombosis with a floating thrombus. Effective fibrinolysis was observed in thromboses of up to 3 months duration. There was no correlation between biological efficacy and clinical symptoms. In conclusion, fibrinolytic drugs are partially effective in semi-recent or chronic venous thrombosis and their usefulness should not be overlooked, especially in cases of persistent thrombosis of the femoral veins.

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Fiessinger, J.N. 1994: Which antithrombotic agents should be prescribed in deep venous thrombosis of the limbs? Presse Medicale 23(11): 509-510
Serradimigni, A.; Romani, A.; Chiche, G.; Elias, A.; Sarlon, R.; Egre, A. 1982: Phlebography in venous thrombosis of the lower limbs Journal des Maladies Vasculaires 7(1): 67-72
Iivanainen, A.; Valtonen, M.; Pentikäinen, P.J.; Rasi, V.; Ikkala, E. 1990: Primary venous thrombosis of the upper limbs Duodecim; Laaketieteellinen Aikakauskirja 106(2): 190-194
Boccalon, H. 1996: Diagnosis of deep venous thrombosis of the lower limbs La Revue du Praticien 46(10): 1211-1217
Bounameaux, H. 1990: Epidemiology and etiopathogenesis of deep venous thrombosis of the lower limbs Agressologie: Revue Internationale de Physio-Biologie et de Pharmacologie Appliquees Aux Effets de l'Agression 31(3): 141-143
Karaharju, E.O.; Hakkiluoto, A. 1972: Ultrasonic flow detection in the diagnosis of venous thrombosis in the lower limbs Annales Chirurgiae et Gynaecologiae Fenniae 61(1): 23-24
Gillet, J.L.; Perrin, M.; Cayman, R. 2001: Superficial venous thrombosis of the lower limbs: prospective analysis in 100 patients Journal des Maladies Vasculaires 26(1): 16-22
Jacquin, V.; Salama, J.; Le Roux, G.; Delaporte, P. 1988: Venous thrombosis in the brain and upper limbs associated with thrombopenia induced by pentosan polysulfate Annales de Medecine Interne 139(3): 194-197
Lombardi, A.A.; Miselli, A.; Bresciani, P.; Soana, G.; Cocchi, S. 1998: Color Doppler echography in the diagnosis of deep venous thrombosis of the lower limbs Acta Bio-Medica de l'Ateneo Parmense 69(3-4): 105-112
Valentin, J.; Léonhardt, D.; Perrin, M. 1988: Prevention of venous thromboses and cutaneous necroses using physical methods and pressure therapy in the surgery of chronic venous insufficiency of the lower limbs Phlebologie 41(3): 690-696
Chanu, B.; Bakir, R.; Djian, F.; Monsuez, J.J.; Aubert, I.; Rouffy, J. 1986: Pseudophlebitis of the lower limbs. a critical study from 102 suspected cases of deep venous thrombosis Annales de Medecine Interne 137(6): 488-492
Vuillemenot, A.; Bassand, J.P. 1994: Deep venous thrombosis of the lower limbs. Etiology, physiopathology, diagnosis, course, prognosis, treatment La Revue du Praticien 44(1): 109-117
Mannuccio Mannucci, P.; Altieri, D.; Mari, D. 1987: Thrombolytic therapy in acute deep venous thrombosis of the lower limbs: selection, indications and limits Minerva Chirurgica 42(23-24): 2031-2035
Woolson, S.T.; McCrory, D.W.; Walter, J.F.; Maloney, W.J.; Watt, J.M.; Cahill, P.D. 1990: B-mode ultrasound scanning in the detection of proximal venous thrombosis after total hip replacement Journal of Bone and Joint Surgery. American Volume 72(7): 983-987
Malone, P.C.; Agutter, P.S. 2009: To what extent might deep venous thrombosis and chronic venous insufficiency share a common etiology? International Angiology: a Journal of the International Union of Angiology 28(4): 254-268
Boesplug, O. 1982: Doppler examination. Specificity and sensibility in comparison with standard phlebography in recent deep venous thrombosis of the lower limbs Journal des Maladies Vasculaires 7(1): 77-80
Lamy, O.; Cornuz, J.; Yersin, B. 1999: Treatment of proximal deep venous thrombosis of the legs by low-molecular-weight heparin: a systematic review Schweizerische Medizinische Wochenschrift 129(18): 707-714
Smith, R.A.; Dupe, R.J.; English, P.D.; Green, J. 1982: Acyl-enzymes as thrombolytic agents in a rabbit model of venous thrombosis Thrombosis and Haemostasis 47(3): 269-274
Perrin, M.; Nicolini, P. 1997: Reconstructive surgery in chronic venous disease of the lower limbs Revue Medicale de la Suisse Romande 117(2): 113-116
Laurian, C.; Gigou, F.; Brisset, D. 1994: Rare forms of chronic venous insufficiency of the lower limbs La Revue du Praticien 44(6): 751-755