Cerebral metastasis of choriocarcinoma
Kaseki, S.; Ishizuka, T.; Nishikawa, Y.; Hirokawa, K.; Goto, S.; Kaseki, H.; Hara, T.; Tomoda, Y.
Gan no Rinsho. Japan Journal of Cancer Clinics 30(9 Suppl): 1002-1009
1984
ISSN/ISBN: 0021-4949 PMID: 6088832 Document Number: 226619
One hundred and eighty-two cases of choriocarcinoma were treated in our clinic during the 26 years period from 1957 to 1982. Forty-one patients among them (2.3%) had cerebral metastases. Analysis on the autopsy findings of patients with cerebral metastases of choriocarcinoma proved neurosurgical resectability in most cases. Craniotomy and removal of cerebral metastatic lesion has been adopted since 1972, and a significant difference was noted in the surviving time between surgically treated group and the group without surgery. The risk factors for developing brain metastases were analyzed. Patients whose uterine lesion showed immature type of histopathology (p less than 0.01), patients without uterine lesion (p less than 0.05) and patients with pulmonary metastasis (p less than 0.01) had higher risk of developing cerebral metastasis.