Early cellular and biochemical alveolar responses following intra-tracheal inoculation with low dose of asbestos and quartz
Le Maho, S.; Bignon, J.; Lambre, C.; Jaurand, M.C.; Masse, R.
Archivum Immunologiae et Therapiae Experimentalis 32(1): 85-98
1984
ISSN/ISBN: 0004-069X PMID: 6089694 Document Number: 226316
The study of broncho-alveolar lavage harvested from rats intratracheally dusted with chrysotile (0.5 mg), leached chrysotile (0.5 mg), crocidolite (0.5 mg) and quartz (0.5 and 5 mg) indicated; a cytotoxic lysis of alveolar macrophages in relation to phagocytosis of dust particles in the following decreasing order; quartz, crocidolite, chrysotile. Regarding cell intensity and duration while asbestos, even leached chrysotile, gave merely an early and transient response. This cell recruitment concerned mostly polymorphonuclear leukocytes and to a lesser extent alveolar macrophage. Cell recruitment was associated with an increased protein and phospholipid alveolar content. The increase of proteins probably came mostly from an inflammatory serum exudate. An increase in the synthesis of complement C3 and phospholipids is not excluded.