Monounsaturated fatty acid (avocado) rich diet for mild hypercholesterolemia
López Ledesma, R.; Frati Munari, A.C.; Hernández Domínguez, B.C.; Cervantes Montalvo, S.; Hernández Luna, M.H.; Juárez, C.; Morán Lira, S.
Archives of Medical Research 27(4): 519-523
1996
ISSN/ISBN: 0188-4409 PMID: 8987188 Document Number: 226
The effect of a high monoenoic fatty acids (MFA) diet on blood lipids was investigated. 30 healthy normolipaemic volunteers (14 women and 16 men; 18-30 years old) and 37 subjects with mild hypercholesterolaemia (5.4-9.3 mmol/litre; 25 women and 12 men; 35-65 years old) were studied. 15 of the hypercholesterolaemic subjects also had hypertriglyceridaemia (2.3-4.8 mmol/litre). 15 healthy and 30 hypercholesterolaemic subjects (15 of them with associated type 2 diabetes mellitus) were fed on an avocado enriched diet (2000 Kcal; lipids 53%; MFA 49 g; saturated:unsaturated ratio 0.54). 7 non-diabetic hypercholesterolaemic subjects were fed on an isoenergetic control diet (MFA 34 g; saturated:unsaturated ratio 0.7). Serum total cholesterol, LDL-cholesterol, HDL-cholesterol and triacylglycerol concentrations were measured before and after a 7-day diet period. In healthy subjects, serum total cholesterol concentration decreased (by 16%) after the MFA diet, while it increased after the control diet (P<0.001 between diets). In hypercholesterolaemic subjects a decrease (P<0.01) in serum total cholesterol (17%), LDL-cholesterol (22%) and triacylglycerols (22%), and increase in HDL-cholesterol (11%) concentrations occurred with the avocado diet, while no changes occurred with the control diet. It is concluded that a high lipid, high MFA-avocado enriched diet can improve lipid profiles in healthy and mildly hypercholesterolaemic subjects, even if hypertriglyceridaemia (combined hyperlipaemia) is present.
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