Effect of naloxone on gastric emptying during labour
Frame, W.T.; Allison, R.H.; Moir, D.D.; Nimmo, W.S.
British Journal of Anaesthesia 56(3): 263-266
1984
ISSN/ISBN: 0007-0912 PMID: 6704275 Document Number: 225795
The rate of gastric emptying was studied in 30 women during labor. All the women had received pethidine 100 mg i.m. for analgesia and, subsequently, extradural analgesia had been established for obstetric indications. The women were allocated randomly to 2 groups: 15 received naloxone 1.2 mg i.v. and 15 were given saline 3 ml (placebo). All 30 patients were then given paracetamol 1.5 g orally with water 100 ml. The amount of paracetamol absorbed, and hence gastric emptying, was significantly greater in the naloxone group in the 1st 30 min following the administration of the paracetamol.