Intramuscular premedication with diazepam in a fat emulsion
Faré, J.C.; Guesnon, P.; Helouis, J.J.; Normand, S.; André, J.L.; Duvaldestin, P.
Cahiers d'Anesthesiologie 32(4): 303-306
1984
ISSN/ISBN: 0007-9685 PMID: 6529665 Document Number: 225195
10 mg of diazepam in fat emulsion was given for premedication intramuscularly to 106 patients. In 53% of the cases patients were well sedated, 33% were apprehensive, 14% anxious. Pain related to the injection was complained of by 4 patients. Plasma concentration of diazepam at induction (60 minutes after the injection) was 130 ng/ml. Compared to diazepam in propylene glycol, pain at the injection side was less frequent while the level of sedation and the plasma concentration of diazepam were similar.