Ultrastructural stereological analysis of acute myocardial hypertrophy of hypertensive etiology
Lushnikova, E.L.; Nepomniashchikh, L.M.; Tumanov, V.P.; Nepomniashchikh, G.I.; Gonchar, A.M.
Biulleten' Eksperimental'noi Biologii i Meditsiny 97(3): 366-370
1984
ISSN/ISBN: 0365-9615 PMID: 6231065 Document Number: 224314
The myocardium of Wistar rats was studied by electron microscopy after ligation of the renal artery resulting in a stable elevation of blood pressure. The ultrastructural data on the development of heart hypertrophy were described within 5 to 35 days after operation using the morphometric and stereological methods and correlation analysis. The hypertrophied cardiomyocytes showed a reduction in the ratio of the total volume density of the mitochondria, sarcoplasmic reticulum and T system to the volume density of myofibrils. It was discovered that hypertrophy of cardiomyocytes is marked by an increase in the sarcoplasmic reticulum rather than in myofibrils and other cell compartments, whereas the relative volume of mitochondria decreases.