Renal tubular acidosis associated with vitamin D-resistant rickets. Role of phosphate depletion
Minari, M.; Castellani, A.; Garella, S.
Mineral and Electrolyte Metabolism 10(6): 371-374
1984
ISSN/ISBN: 0378-0392 PMID: 6095003 Document Number: 224141
3 children with vitamin D-resistant rickets (VDRR), and severe phosphate depletion had moderate metabolitic acidosis and evidence of impaired distal tubular acidifying mechanisms. Therapy with 1-alpha-OH-vitamin D3 and phosphate supplementation improved the clinical and radiological rachitic manifestations, and resulted in the normalization of systemic acid-base parameters as well as of tubular acidification. Profound phosphate depletion is another cause of acquired, reversible distal renal tubular acidosis (RTA).