Predicting pregnancy in HIV-1-discordant couples
Guthrie, B.L.; Choi, R.Y.; Bosire, R.; Kiarie, J.N.; Mackelprang, R.D.; Gatuguta, A.; John-Stewart, G.C.; Farquhar, C.
Aids and Behavior 14(5): 1066-1071
2010
ISSN/ISBN: 1573-3254 PMID: 20544384 DOI: 10.1007/s10461-010-9716-xDocument Number: 223325
This study examines the incidence and predictors of pregnancy in HIV-1-discordant couples from Nairobi, Kenya. Women from 454 discordant couples were followed for up to 2 years. One-year cumulative incidence of pregnancy was 9.7%. Pregnancy rates did not differ significantly between HIV-1-infected and uninfected women (HR = 1.46). The majority of pregnancies occurred among women < 30 years old reporting a desire for future children (1-year incidence 22.2%). Pregnancy rates may be high among discordant couples, indicating desire for children may override concerns of HIV-1 transmission and increase unprotected sex, and highlighting the need to make conception safer.