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Bleomycin-induced early-onset transient decrease in platelet counts

Verwey, J.; Breed, W.P.; Hillen, H.F.

Netherlands Journal of Medicine 27(6): 202-205

1984

ISSN/ISBN: 0300-2977
PMID: 6205282
Document Number: 222724
Platelet counts were followed on 5 successive days after giving bleomycin-including chemotherapy in a total of 19 patients and compared with similar counts in 11 patients given chemotherapy without bleomycin. Bleomycin appears to cause a rapid decrease in platelet counts with a nadir after 2 days, while the non-bleomycin-treated patients did not show this decrease. The difference on the day of nadir was statistically significant. Heparin did not prevent the observed phenomenon. A possible association between the rapid decrease in platelet counts and development of bleomycin-induced pulmonary fibrosis is discussed.

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