Dose-independence of early, cyclophosphamide-induced lung damage in mice
Depledge, M.H.
Japanese Journal of Experimental Medicine 54(6): 235-239
1984
ISSN/ISBN: 0021-5031 PMID: 6535853 Document Number: 222674
Administration of cyclophosphamide to mice resulted in lung damage which was assessed by measuring breathing rate and lung compliance. Above a threshold dose (approximately 50-100 mg/kg b.w.) the time of onset and severity of early, acute pulmonary dysfunction was dose-independent in the range 100-400 mg/kg. At doses up to 200 mg/kg lung damage was reversible but above this second threshold level, pulmonary fibrosis invariably developed. The severity of late damage (approximately day 40) was dose-related. These findings may help in the interpretation of clinical lung damage associated with cyclophosphamide therapy.