Etiopathogenic factors possibly implicated in hepatic dysfunction associated with parenteral nutrition: prospective study of 104 adult patients
Pallarés, R.; Sitges-Serra, A.; Fuentes, J.; Jaurrieta, E.; Guardia, J.; Fernández-Nogués, F.; Sitges-Creus, A.
Medicina Clinica 83(20): 832-836
1984
ISSN/ISBN: 0025-7753 PMID: 6441876 Document Number: 222186
During parenteral nutrition (NP), 78% of 60 patients without evidence of previous hepatic dysfunction developed moderate abnormalities of the liver function tests. .gamma.-Glutamyltransferase (GGT) was the most abnormal parameter followed by alkaline phosphatase (FA), transaminases and bilirubin. Patients who received NP with an oral diet did not have hepatic abnormalities or they were less significant than those found among patients receiving NP only. Patients who developed sepsis had more marked elevations of the bilirubin and those who underwent survey had higher elevations of GGT and FA. Patients who received > 2 mg/kg per day of lipids developed more significant elevations of FA and bilirubin and those patients whe received > 0.30 g/kg per day of nitrogen had higher concentrations of bilirubin. This study suggests that hepatic dysfunction associated to NP could be due to the absence of oral intake. The presence of sepsis, surgical interventions, and maybe the administration of elevated quantities of nutrients may constitute aggravating factors of these abnormalities.