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Correlation between serum concentration and hypoglycemic effect of chlorpropamide in man

Jankowski, A.; Wichliński, L.M.; Bokowski, W.; Romański, B.

Polish Journal of Pharmacology and Pharmacy 36(5): 449-453

1984

ISSN/ISBN: 0301-0244
PMID: 6533629
Document Number: 222148
The relationship between the serum concentration and some of pharmacokinetic parameters of chlorpropamide and the hypoglycemic effect of this drug was studied. Studies were carried out in a group of 18 patients in whom the concentrations of drug and sugar in blood were determined simultaneously. Close correlation between the concentration and some pharmacokinetic parameters of chlorpropamide and the intensity of decrease of the blood glucose level as well as the time of its occurrence has been found.

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